Femoral artery atrophy following prolonged reduced hindlimb activity

  • 75 Pages
  • 0.38 MB
  • English

Femoral artery., Blood flow., Rats -- Exercise -- Physiological asp
Statementby Herbert G. Chew, Jr.
The Physical Object
Paginationviii, 75 leaves
ID Numbers
Open LibraryOL15523822M

Get this from a library. Femoral artery atrophy following prolonged reduced hindlimb activity. [Herbert G Chew]. Group HI: The femoral artery of the right hindlimb of each rat in this group was exposed aseptically through a 1 cm skin incision and gently separated from the femoral vein and nerve.

Two ligations were made around the femoral artery: one proximal to the bifurcation of the popliteal artery and saphenous artery and the other distal to the Cited by: 6.

Hindlimb Blood Flow Recovery After Femoral Artery Ligation. In control mice, blood flow fell precipitously after surgery, remained impaired for 3 days, increased to 70% of the nonischemic limb by day 7, and ultimately returned to near-normal levels by day Cited by: Hindlimb atrophy and histological analysis of the deep femoral artery (DFA) in a unilateral sciatic denervation model.

A: sciatic nerve surgery (left) and appearance of the hindlimb at week 3 post-operation (right). B: schedule of denervation (Operation) and exercise training.

Names of the experimental groups are indicated in red: sedentary 3. The rat model of hindlimb ischemia induced by femoral artery ligation showed decreased blood flow in muscles of the hindlimb, such as the gastrocnemius ( ± vs. ± mL/min/g, P Cited by: CQ reduces hindlimb perfusion recovery after femoral artery ligation (FAL).

a Laser Doppler Perfusion Imaging (LDPI) of C57Bl6/J (WT) and caspase-1/11KO treated with either CQ or PBS (control) over the course of the study.

LDPI was performed just before ligation (Day 0), and 1, 7, 14 and 21 days after FAL on the right hindlimb (screen left on. Introduction. The presence of sedentary behavior is Femoral artery atrophy following prolonged reduced hindlimb activity book major concern in today’s society [].There are numerous sitting opportunities throughout the day and the average sitting time for American adults is ~8 hr/day [].Sitting creates a unique anatomical and physiological milieu in the legs including bends in the femoral and popliteal artery, increased viscosity [], blood pressure [] and.

Mice were subsequently subjected to unilateral external iliac and femoral artery ligation to induce severe hindlimb ischemia [23], [25].

A complete loss of locomotion of the injured hindlimb was immediately observed in with this treatment. Analysis of tissue. Discussion. The femoral artery is felt as a cylinder or tube, with the center line as the highest point, with the edges of the tube lower on each side. The femoral artery pulse is thus located (Figure 2).

Local anesthesia is given next (see The Cardiac Catheterization Handbook, 5th edition, page 51). Femoral artery ligation. All protocols were approved by the Institutional Animal Care and Use Committee. Femoral artery ligation (unilateral or bilateral) was performed under intraperitoneal pentobarbital sodium (50 mg/kg) anesthesia as previously described (26, 32).Briefly, strict aseptic conditions were implemented before the skin was opened at the medial thigh region.

Description Femoral artery atrophy following prolonged reduced hindlimb activity FB2

Hindlimb unweighting via tail suspension has been shown to cause marked skeletal muscle atrophy and, consistent with previous studies (Musacchia et al. ; McDonald et al. ), soleus and medial and lateral gastrocnemius muscle mass was reduced in HU compared with S rats in the present study. Bernd Antkowiak, in Advances in Pharmacology, 13 Spinal Actions of Etomidate.

The hindlimb withdrawal reflex is commonly used as a measure of the immobilizing activity of drugs. In β2-knockin mice, the duration of the loss of the hindlimb withdrawal reflex after intravenous injection of 10 and 15 mg/kg etomidate was somewhat shorter than in wild-type animals (Reynolds et al., ).

The range of adaptation by collateral vessels after femoral artery occlusion. Circ Res. ; – Link Google Scholar; 7 Holman E. Problems in the dynamics of blood flow; conditions controlling collateral circulation in the presence of an arteriovenous fistula, following the ligation of an artery.

Surgery. ; –,illust. Ghotbi, R. Mansour, in Computing and Visualization for Intravascular Imaging and Computer-Assisted Stenting, Graft Insertion. The common femoral artery is normally exposed with a surgical cut-down on both sides.

The current method of using low-profile devices and sealing systems allow an entirely percutaneous approach. Legg–Calvé–Perthes disease (LCPD), is a childhood hip disorder initiated by a disruption of blood flow to the head of the to the lack of blood flow, the bone dies (osteonecrosis or avascular necrosis) and stops time, healing occurs by new blood vessels infiltrating the dead bone and removing the necrotic bone which leads to a loss of bone mass and a weakening of the.

It is unknown if there are limb differences in vascular function during prolonged sitting.

Details Femoral artery atrophy following prolonged reduced hindlimb activity FB2

This study was designed to test whether the effects of prolonged sitting on brachial artery (BA) and the superficial femoral artery (SFA) are similar. Twelve men ( ± 4 yrs.) participated in a 3 hr prolonged sitting trial (SIT). SFA and BA flow mediated dilation (FMD) and respective flow patterns.

Article. Drag-reducing polymers increase exercise tolerance in an ischemic hind-limb rat model. June ; Vascular 24(3). The femoral artery is a large artery in the thigh and the main arterial supply to the thigh and leg.

It enters the thigh from behind the inguinal ligament as the continuation of the external iliac artery. Here, it lies midway between the anterior superior iliac spine and the symphysis femoral artery gives off the deep femoral artery or profunda femoris artery and descends along the.

The femoral artery catheter was used for the continuous infusion of p-amino hippurate (PAH) to measure plasma flow across hindlimb muscle. The jugular vein was used for infusion of NaH 13 CO 3 and [ C]leucine to measure leucine metabolism in hindlimb muscle.

Carotid artery and femoral vein catheters were used for blood collection. Request PDF | Vascular smooth muscle hypersensitivity to constrictor influence after denervation and in chronic hypotension | Changes in contractile activity of saphenous artery in normotensive. Effect of prolonged ischaemic time on muscular atrophy and regenerating nerve fibres in transplantation of the rat hind limb femoral artery was ligated through an Muscle mass decreased in.

The femoral artery is one of the major arteries in the human body. It extends from the iliac artery near the abdomen down to the legs. The primary function of this artery. We hypothesized that the structure of systemic arteries would be altered following wk of hindlimb unloading (tail suspension) in female Sprague-Dawley rats.

Tail suspension resulted in atrophy of the soleus muscle(P ≤ ) but no significant differences in the mass of the extensor digitorum muscle, heart, or adrenal glands.

Download Femoral artery atrophy following prolonged reduced hindlimb activity EPUB

In anesthetized rats, there was no difference between groups. Induction of hindlimb ischemia. Surgery was performed under isoflurane anesthesia (2%) to create unilateral hindlimb ischemia in the mice according to techniques previously described [1, 8, 35, 40].Briefly, an incision in the skin overlying the middle portion of the right hindlimb of each mouse exposed the femoral artery.

Simultaneous bilateral EDL force and hindlimb blood flow measurements were made during electrical stimulation. Following functional capillary rarefaction there was an acute microsphere dose‐dependent reduction in muscle fatigue resistance (P femoral artery perfusion.

We tested the hypothesis that hindlimb unweighting (HLU) decreases endothelium-dependent vasodilation and expression of endothelial nitric oxide synthase (eNOS) and superoxide dismutase-1.

Peripheral arterial disease (PAD) is atherosclerosis leading to narrowing of the major arteries distal to the aortic arch. The most common presenting symptom is. The femoral arteries (you have two) start at the bottom of the aorta (the main artery that comes off the heart and then heads south through your stomach area toward your legs) when it splits in your lower abdomen, sending one branch down the right.

the metabolic syndrome X is an emerging epidemic in Western cultures and consists of the combined presentation of multiple cardiovascular risk factors ().These factors, including hypertension, insulin resistance, and obesity, directly contribute to the higher incidence of cardiovascular diseases, including peripheral vascular disease, coronary artery disease, and renal disease found in.

peripheral artery occlusive disease results in diminished blood flow to tissue downstream of the obstruction. In humans, complications resulting from peripheral arterial insufficiency include limb pain during daily activities such as walking and stair climbing, often with a progression to pain at rest, and all too frequently ulceration that can lead to gangrene and amputation ().

Therefore, blood flow to the hindlimb after removal of the femoral artery is dependent upon flow from the internal iliac artery and collateral vessels. All rabbits were closely monitored by veterinary staff and received an analgesic (buprenorphine, mg/kg s.c., b.i.d.) and antibiotic (enrofloxacin, mg/kg, s.c.) for 3 days following surgery.The femoral artery was exposed aseptically through a 2-mm incision and isolated from the femoral vein and nerve, with care taken to avoid damage to vessels or nerve.

The femoral artery was ligated with suture just distal to the bifurcation of the anterior epigastric and lateral caudal femoral arteries (LCFA).Related Disorders. Aortic thrombosis (ATh) is associated with any of several other disorders, including protein losing nephropathy (PLN) due to liver disorders which is the most consistently diagnosed concurrent disease in dogs.

Others include diabetes mellitus, hypothyroidism, Cushing’s Disease (hyperadrenocorticism or HAC), and immune-mediated thrombocytopenia (ITP).